
PRESENTATION
AGE:
28 Years
CHIEF COMPLAINT:
“Fuzzy lump” on inner aspect of lower lip
DURATION:
2-3 weeks
Figure 1: Lower Labial Mucosa
HISTORY
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Significant stress and sleep deprivation before onset
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Intermittent erythema and burning sensation
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Lesions fluctuate in intensity
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Similar smaller lesions adjacent to original site and near upper labial commissures
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Mild intermittent tonsillar discomfort and recent self-limiting sore throat
CLINICAL FINDINGS
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Corrugated mildly erythematous patch, faint yellow background, raised red border
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Rough texture on palpation
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Burning sensation
ADDITIONAL FINDINGS
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Asymmetrical tonsillar enlargement with focal calcification
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Multiple oral exostoses and tori
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No cervical lymphadenopathy
WHAT IS THE
MOST LIKELY DIAGNOSIS?
A: Oral candidosis
B: Oral lichen planus
C: Erythroplakia​
D: Erythema migrans
E: Contact mucositis

Figure 2: Incisional biopsy
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Non-specific inflammatory mucositis
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No dysplasia or malignancy
KEY LEARNING POINTS
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Erythema migrans can affect extra-lingual sites including the labial and buccal mucosa
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Lesions may fluctuate in appearance and symptoms, mimicking more concerning inflammatory or dysplastic conditions
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Stress, sleep deprivation, spicy foods, and local irritants may exacerbate symptoms
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Histopathology is often non-specific and primarily useful for excluding dysplasia or other pathology
MANAGEMENT
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Comprehensive intra-oral and head and neck examination including lymph node assessment
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Clinical photography and review of lesion fluctuation over time
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Incisional biopsy to exclude dysplasia or malignancy
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Consider investigation for nutritional deficiencies or associated systemic factors if persistent or recurrent
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Explanation regarding benign immune-mediated and migratory nature of condition
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Avoidance of triggering foods and irritating oral hygiene products
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Consider transition to non-irritating toothpaste formulations for symptomatic patients
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Mild topical corticosteroid such as triamcinolone in orabase for symptomatic flares


